Pharmacokinetic disposition in oral fluid, excretion profile, and subjective and physiological responses following oral and intranasal administration of Clophedrone (3-CMC)
October 13, 2026 Nunzia La Maida, Lourdes Poyatos, Annagiulia Di Trana et al.
Background and Purpose: Clophedrone (3-chloromethcathinone, 3-CMC) belongs to the methcathinone subclass of ring-substituted cathinones, a prominent group of new psychoactive substances (NPS) present in the illicit drug market. To date no studies have assessed concentrations and acute effects of 3-CMC in humans after self-administration. Experimental Approach: A total of 16 psychostimulant...