Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors.
Pharmacological Research December 2021 Iu Raïch, Rafael Rivas-Santisteban, Alejandro Lillo et al.
We have here assessed, using Δ9-tetrahydrocannabinol (Δ9-THC) for comparison, the effect of Δ9-tetrahydrocannabinolic acid (Δ9-THCA) and of Δ9-tetrahydrocannabivarin (Δ9-THCV) that is mediated by human versions of CB1, CB2, and CB1-CB2 receptor functional units, expressed in a heterologous system. Binding to the CB1 and CB2 receptors was addressed in living cells by means of a homogeneous...
DOI: 10.1016/j.phrs.2021.105970 (opens in new tab)
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Bitopic drug
Cb1-cb2 receptor heteromers
Cannabis sativa l
Exosite
+2