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Mark Picard

1 paper in the library · publishing 2026

Papers

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A Harm-Reduction–Oriented Clinical Framework for Ibogaine Administration and Risk Management

October 3, 2026 Mark Picard preprint

Ibogaine is a psychoactive indole alkaloid with reported potential to interrupt opioid withdrawal and reduce substance use. Despite increasing interest in its therapeutic applications, ibogaine administration remains associated with significant risk, particularly related to cardiac conduction abnormalities and autonomic instability. Most serious adverse events appear to arise from identifiable...