David M Christmas

Equivalent effects of acute tryptophan depletion on REM sleep in ecstasy users and controls.

Psychopharmacology July 8, 2009 Robin Carhart-Harris, David Nutt, Marcus R. Munafò et al.

Introduction: This study sought to test the association between 3,4-methylenedioxymethamphetamine use, serotonergic function and sleep. Materials and methods: Ambulatory polysomnography was used to measure three nights sleep in 12 ecstasy users and 12 controls after screening (no intervention), a tryptophan-free amino acid mixture (acute tryptophan depletion (ATD)) and a tryptophan-supplemented...