Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge.
Neuroimage May 6, 2010 Paul R A Stokes, Alice Egerton, Ben Watson et al.
Delta9-tetrahydrocannabinol (THC) increases prefrontal cortical dopamine release in animals, but this is yet to be examined in humans. In man, striatal dopamine release can be indexed using [11C]-raclopride positron emission tomography (PET), and recent reports suggest that cortical [11C]-raclopride binding may also be sensitive to dopaminergic challenges. Using an existing dataset we examined...
DOI: 10.1016/j.neuroimage.2010.04.274 (opens in new tab)
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Frontal lobe
Temporal lobe
Humans
Raclopride
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