Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration.
Pharmacological Research April 2008 Raffaella Molteni, Matteo Pasini, Stefania Moraschi et al.
Evidence exists that schizophrenia is characterized by deficits in cell-cell communication and information processing. In the present study, we used the phencyclidine (PCP) animal model of schizophrenia to investigate possible defects in intracellular signaling proteins involved in neuroplasticity. Western Blot analysis has been performed to determine total and phospho-protein levels of...