Marijuana (MJ) acutely acts on cannabinoid receptors that are found in numerous brain regions, including those involved in reward processing and decision-making. However, it remains unclear how long-term, chronic MJ use alters reward-based decision-making. In the present study, using [(15)O]water PET imaging, we measured brain activity in chronic MJ users, who underwent monitored abstinence...
It is uncertain whether frequent marijuana use adversely affects human brain function. Using positron emission tomography (PET), memory-related regional cerebral blood flow was compared in frequent marijuana users and nonusing control subjects after 26+ h of monitored abstention. Memory-related blood flow in marijuana users, relative to control subjects, showed decreases in prefrontal cortex,...
AbstractSubjects (16 men and 16 women) breathing 30 per cent nitrous oxide in oxygen, or 100 per cent oxygen, were tested to see if the effects of nitrous oxide on memory varied with different types of auditory stimuli and memory‐testing procedures. The drug produced substantial memory impairments. These impairments were milder in forced‐choice recognition than in yes/no recognition and for...