Hidemi Ishii

2 papers in the library · publishing 2009-2010

Papers

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Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes.

Chemico-Biological Interactions September 15, 2010 Yoshio Nakagawa, Toshinari Suzuki, Hidemi Ishii et al.

The cytotoxic effects and biotransformation of harmine and harmaline, which are known β-carboline alkaloids and potent hallucinogens, were studied in freshly isolated rat hepatocytes. The exposure of hepatocytes to harmine caused not only concentration (0-0.50mM)- and time (0-3h)-dependent cell death accompanied by the formation of cell blebs and the loss of cellular ATP, reduced glutathione,...

DOI: 10.1016/j.cbi.2010.09.004 Full text Hepatocytes Animals Rats Malondialdehyde +11

Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes.

Archives of Toxicology January 2009 Yoshio Nakagawa, Toshinari Suzuki, Sumiko Tayama et al.

The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4-(methylenedioxyphenyl)-2-butanamine (BDB) and...

DOI: 10.1007/s00204-008-0323-9 Full text