Brenda J Gehrke

Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum.

Psychopharmacology April 2008 Brenda J Gehrke, Vladimir I Chefer, Toni S Shippenberg

Acute systemic administration of salvinorin A, a naturally occurring kappa-opioid receptor (KOPr) agonist, decreases locomotion and striatal dopamine (DA) overflow. Conventional and quantitative microdialysis techniques were used to determine whether salvinorin A infusion into the dorsal striatum (DSTR) decreases DA overflow by altering DA uptake or release. The influence of repeated salvinorin...