Beth A Toth

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist.

Journal of Medicinal Chemistry January 27, 2005 Thomas A Munro, Mark A Rizzacasa, Bryan L. Roth et al.

Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective kappa opioid receptor (KOR) agonist. We screened other salvinorins and derivatives for binding affinity and functional activity at opioid receptors. Our results suggest that the methyl ester and furan ring are required for activity but that the lactone and ketone functionalities are not. Other salvinorins showed...