The LancetAugust 15, 2009Sanjeev Bhattacharyya, Anthony H Schapira, Dimitri P Mikhailidis et al.
The initial association between the development of valvular heart disease and drugs stems from observations made during the use of methysergide and ergotamine for migraine prophylaxis in the 1960s. Since then, the appetite suppressants fenfluramine and dexfenfluramine, the dopamine agonists pergolide and cabergoline, and more recently, the recreational drug ecstasy (3,4...