Jesse A May

2 papers in the library · publishing 2004-2008

Papers

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Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine].

Pharmacology, Biochemistry, and Behavior July 30, 2008 Jesse A May, Najam A Sharif, Hwang-Hsing Chen et al.

AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT2 receptor subtypes (Ki100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displayed a very low affinity for a broad array of other receptors, neurotransmitter transport sites, ion channels, and second messenger elements, making it a relatively selective agent....

DOI: 10.1016/j.pbb.2008.07.015 Full text Stomach Animals Macaca mulatta Humans +19

Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.

Journal of Medicinal Chemistry November 18, 2004 Richard A Glennon, Mikhail L Bondarev, Nantaka Khorana et al.

Activation of 5-HT(2A) serotonin receptors represents a novel approach to lowering intraocular pressure. Because 5-HT(2A) serotonin receptor agonists might also produce undesirable central effects should sufficient quantities enter the brain, attempts were made to identify 5-HT(2) serotonin receptor agonists with reduced propensity to penetrate the blood-brain barrier....

DOI: 10.1021/jm040082s Full text