Opioid gene expression changes and post-translational histone modifications at promoter regions in the rat nucleus accumbens after acute and repeated 3,4-methylenedioxy-methamphetamine (MDMA) exposure.
Pharmacological Research December 2016 Francesca Felicia Caputi, Martina Palmisano, Lucia Carboni et al.
The recreational drug of abuse 3,4-methylenedioxymethamphetamine (MDMA) has been shown to produce neurotoxic damage and long-lasting changes in several brain areas. In addition to the involvement of serotoninergic and dopaminergic systems, little information exists about the contribution of nociceptin/orphaninFQ (N/OFQ)-NOP and dynorphin (DYN)-KOP systems in neuronal adaptations evoked by MDMA....
DOI: 10.1016/j.phrs.2016.10.023 (opens in new tab)
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MDMA
Dynorphin
Epigenetics
Histone modification
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