Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats.
Psychopharmacology July 2017 Erin M Rock, Cheryl L Limebeer, Gavin N Petrie et al.
Cannabis is commonly used by humans to relieve stress. Here, we evaluate the potential of intraperitoneally (i.p.) administered Δ9-tetrahydrocannabiol (THC) and cannabidiolic acid (CBDA, the precursor of cannabidiol [CBD]) to produce dose-dependent effects on anxiety-like responding in the light-dark (LD) emergence test of anxiety-like responding in rats, when administered acutely or...
DOI: 10.1007/s00213-017-4626-5 (opens in new tab)
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Anxiety
Anxiolytic
Cannabidiolic acid
Foot shock
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