The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats.
Psychopharmacology July 1, 2024 Dilan Gokalp, Gunes Unal
Ketamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent manner. It has a complex mechanism of action that involve alterations in other glutamate receptors. The metabotropic glutamate receptor 5 (mGluR5) has been investigated in relation to the psychotic and anesthetic properties of ketamine, while its role in mediating the...