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Tatiana Tkatch

1 paper in the library · publishing 2012

Papers

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SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.

Nature Neuroscience January 8, 2012 Cristiano Nazzaro, Barbara Greco, Milica Cerovic et al.

Endocannabinoids (eCBs) regulate neuronal activity in the dorso-lateral striatum (DLS), a brain region that is involved in habitual behaviors. How synaptic eCB signaling contributes to habitual behaviors under physiological and pathological conditions remains unclear. Using a mouse model of cannabinoid tolerance, we found that persistent activation of the eCB pathway impaired eCB-mediated...

DOI: 10.1038/nn.3022 Full text