St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
Behavioural Brain Research December 15, 2014 Martesa Tantra, Tim Kröcher, Sergi Papiol et al.
The neural cell adhesion molecule (NCAM) and its functionally linked polysialyltransferases, ST8SIA2 and ST8SIA4, are crucial for synaptic plasticity. Variations in encoding genes have been associated with mental illness. Since cannabinoids can alter NCAM polysialylation, we hypothesized that delta-9-tetrahydrocannabinol (Δ9-THC) might act as environmental 'second hit' regarding cognition of...
DOI: 10.1016/j.bbr.2014.08.062 (opens in new tab)
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Learning index
Ncam
Polysia
Reference memory
+2