Yu-Yeh Kuo

2 papers in the library · 4 citations · publishing 2022-2024

Papers

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Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals.

Journal of the Chinese Medical Association : JCMA May 1, 2024 Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang et al. 4 citations

The neurotoxicity of 3,4-methylenedioxy-methamphetamine (MDMA) to the serotonergic system is well-documented. Dextromethorphan (DM), an antitussive drug, decreased morphine- or methamphetamine (MA)-induced reward in rats and may prevent MDMA-induced serotonergic deficiency in primates, as indicated by increased serotonin transporter (SERT) availability. We aimed to investigate the effects of DM...

DOI: 10.1097/JCMA.0000000000001087 Full text Addiction research Drug interactions Harm reduction Brain chemistry

Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging

International Journal of Molecular Sciences June 24, 2022 Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo et al.

Numerous studies have confirmed that 3,4-Methylenedioxymethamphetamine (MDMA) produces long-lasting changes to the density of the serotonin reuptake transporter (SERT). Amitriptyline (AMI) has been shown to exert neuroprotective properties in neuropathologic injury. Here, we used a SERT-specific radionuclide, 4-[18F]-ADAM, to assess the longitudinal alterations in SERT binding and evaluate the...

DOI: 10.3390/ijms23137035