Bogna M Ignatowska-Jankowska

2 papers in the library · publishing 2016-2017

Papers

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Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice.

Neuropharmacology October 2017 Robert A Owens, Mohammed A Mustafa, Bogna M Ignatowska-Jankowska et al.

Substantial challenges exist for investigating the cannabinoid receptor type 1 (CB1)-mediated discriminative stimulus effects of the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide; AEA), compared with exogenous CB1 receptor agonists, such as Δ9-tetrahydrocannabinol (THC) and the synthetic cannabinoid CP55,940. Specifically, each endocannabinoid is...

DOI: 10.1016/j.neuropharm.2017.06.032 Full text 2-arachidonoylglycerol 2-ag Cp55,940 pubchem cid Cannabinoid-1 cb1 receptor Diazepam pubchem cid +13

Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice.

Journal of Pharmacology and Experimental Therapeutics August 2016 Robert A Owens, Bogna M Ignatowska-Jankowska, Mohammed A Mustafa et al.

Whereas the inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the respective major hydrolytic enzymes of N-arachidonoyl ethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), elicits no or partial substitution for Δ(9)-tetrahydrocannabinol (THC) in drug-discrimination procedures, combined inhibition of both enzymes fully substitutes for THC, as well as produces a...

DOI: 10.1124/jpet.115.229492 Full text