Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms.
Frontiers in Pharmacology 2014 Petra Amchova, Jana Kučerová, Valentina Giugliano et al.
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with intravenous drug self-administration procedure to verify whether depressive-like rats displayed altered voluntary intake of the CB1 receptor...
DOI: 10.3389/fphar.2014.00044 (opens in new tab)
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Depression
Serotonin
Win55212-2
Cannabinoid
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