Effects of selective calcium-permeable AMPA receptor blockade by IEM 1460 on psychotomimetic-induced hyperactivity in the mouse.
Journal of Neural Transmission April 2018 Masakazu Umino, Asami Umino, Toru Nishikawa
Diminished glutamate neurotransmission via the N-methyl-D-aspartate type glutamate receptor (NMDAR) has been considered to be involved in the pathophysiology of schizophrenia based upon the observation that the antagonists and autoantibodies of NMDAR cause positive, negative and cognitive symptomatologies similar to those of schizophrenia. The possible reduced extracellular levels of D-serine...
DOI: 10.1007/s00702-017-1827-3 (opens in new tab)
Full text (opens in new tab)
Dizocilpine/mk-801
Hyperactivity
Methamphetamine
Phencyclidine
+1