Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.
Drug and Alcohol Dependence October 1, 2018 Kristen R Trexler, Sara R Nass, Molly S Crowe et al.
A subset of cannabis users develop some degree of Cannabis Use Disorder (CUD). Although behavioral therapy has some success in treating CUD, many users relapse, often citing altered sleep, mood, and irritability. Preclinical animal tests of cannabinoid withdrawal focus primarily on somatic-related behaviors precipitated by a cannabinoid receptor antagonist. The goal of the present study was to...
DOI: 10.1016/j.drugalcdep.2018.05.029 (opens in new tab)
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Marijuana
Cannabinoid withdrawal
Cannabis use disorder
Drug dependence
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