Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula.
The international journal of biochemistry & cell biology October 16, 2017 Hugo R Arias, Xiaotao Jin, Dominik Feuerbach et al.
The inhibitory activity of coronaridine congeners on human (h) α4β2 and α7 nicotinic acetylcholine receptors (AChRs) is determined by Ca2+ influx assays, whereas their effects on neurons in the ventral inferior (VI) aspect of the mouse medial habenula (MHb) are determined by patch-clamp recordings. The Ca2+ influx results clearly establish that coronaridine congeners inhibit hα3β4 AChRs with...
DOI: 10.1016/j.biocel.2017.10.006 (opens in new tab)
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Ibogaine
Neurons
Animals
Mice, inbred c57bl
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