John M Streicher

Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Bioorganic & Medicinal Chemistry Letters January 15, 2012 Cécile Béguin, Justin Potuzak, Wei Xu et al.

The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-salvinorin A, a compound which we have previously observed to be a KOPR partial agonist. Five...