Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies.
Acta Neuropsychiatrica August 2017 Sarel Jacobus Brand, Brian Herbert Harvey
Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model of TRD and an abrogated response to imipramine. We extended the investigation by studying the behavioural and monoaminergic response to multiple antidepressants, viz....
DOI: 10.1017/neu.2016.50 (opens in new tab)
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Nmda antagonist
Animal model
Noradrenaline reuptake inhibitor
Serotonin reuptake inhibitor
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