Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine's Rapid Antidepressant Properties.
Biological Psychiatry September 1, 2017 Wallace C. Duncan, Elizabeth E. Slonena, Nadia S. Hejazi et al.
The rapid clinical antidepressant effects of the glutamatergic modulator ketamine may be due to its ability to restore synaptic plasticity and related effects on sleep-wake and circadian systems. Preclinical studies indicate that ketamine alters expression of circadian clock-associated molecules, and clinical studies of ketamine on plasticity-related biomarkers further suggest an association...
DOI: 10.1016/j.biopsych.2017.03.011 (opens in new tab)
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Neuroplasticity
Clock genes
Sleep deprivation
Slow wave sleep
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