Imen Ben Ammar

Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior.

Cell Reports August 22, 2017 Oliver H Miller, Andreas Bruns, Imen Ben Ammar et al.

The NMDA receptor (NMDAR) antagonist ketamine elicits a long-lasting antidepressant response in patients with treatment-resistant depression. Understanding how antagonism of NMDARs alters synapse and circuit function is pivotal to developing circuit-based therapies for depression. Using virally induced gene deletion, ex vivo optogenetic-assisted circuit analysis, and in vivo chemogenetics and...