Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression.
Biochemical Pharmacology June 2018 Ming-Fen Ho, Cristina Correia, James N Ingle et al.
Major depressive disorder (MDD) is the most common psychiatric illness worldwide, and it displays a striking sex-dependent difference in incidence, with two thirds of MDD patients being women. Ketamine treatment can produce rapid antidepressant effects in MDD patients, effects that are mediated-at least partially-through glutamatergic neurotransmission. Two active metabolites of ketamine,...
DOI: 10.1016/j.bcp.2018.03.032 (opens in new tab)
Full text (opens in new tab)
Ampa receptors
Cyp2a6
Cyp2b6
Estrogens
+1