Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of (R,S)-ketamine and (S)-ketamine, but not (R)-ketamine.
Pharmacology, Biochemistry, and Behavior September 2018 Zheng Tian, Chao Dong, Atsuhiro Fujita et al.
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has robust antidepressant effects in depressed patients although it has detrimental side effects such as psychotomimetic and dissociative symptoms. (R,S)-Ketamine is known to cause the expression of heat shock protein HSP-70 (a marker for neuronal injury) in the retrosplenial cortex of rat brain, suggesting that the...
DOI: 10.1016/j.pbb.2018.07.003 (opens in new tab)
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R-ketamine
S-ketamine
Heat shock protein
Neurotoxicity
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