Alexandre Bouron

Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice.

Frontiers in Molecular Neuroscience 2018 Bartłomiej Pochwat, Bernadeta Szewczyk, Katarzyna Kotarska et al.

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action that involves the activation of Ca2+ dependent signaling pathways. Moreover, ketamine, a global NMDAR antagonist is a potent, novel, and atypical drug that has been successfully used to treat major depressive disorder (MDD). However, because...