Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[¹⁸F]-ADAM/small-animal PET study.
European Neuropsychopharmacology January 2016 Jui-Hu Shih, Kuo-Hsing Ma, Chien-Fu F Chen et al.
The misuse of 3,4-methylenedioxymethamphetamine (MDMA) has drawn a growing concern worldwide for its psychophysiological impacts on humans. MDMA abusers are often accompanied by long-term serotonergic neurotoxicity, which is associated with reduced density of cerebral serotonin transporters (SERT) and depressive disorders. Resveratrol (RSV) is a natural polyphenolic phytoalexin that has been...
DOI: 10.1016/j.euroneuro.2015.11.001 (opens in new tab)
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MDMA
4-18f-adam
Occupancy
Resveratrol
+2