Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking behaviors by the CB1 cannabinoid receptor antagonist AM251.
Drug and Alcohol Dependence March 1, 2016 Yoko Nawata, Kiyoyuki Kitaichi, Tsuneyuki Yamamoto
3,4-Methylenedioxymethamphetamine (MDMA), a methamphetamine (METH) derivative, exhibits METH-like actions at monoamine transporters and positive reinforcing effects in rodents and primates. The purposes of the present study were to determine whether cross-reinstatement would be observed between MDMA and METH and if the cannabinoid receptor, a receptor known to play critical roles in the brain...
DOI: 10.1016/j.drugalcdep.2015.12.016 (opens in new tab)
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MDMA
Cb1 cannabinoid receptor
Drug-seeking behavior
Methamphetamine
+1