MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.
Neurotoxicology December 2016 Courtney L Huff, Rachel L Morano, James P Herman et al.
3,4-Methylenedioxy-methamphetamine (MDMA) is a unique psychostimulant that continues to be a popular drug of abuse. It has been well documented that MDMA reduces markers of 5-HT axon terminals in rodents, as well as humans. A loss of parvalbumin-immunoreactive (IR) interneurons in the hippocampus following MDMA treatment has only been documented recently. In the present study, we tested the...
DOI: 10.1016/j.neuro.2016.10.011 (opens in new tab)
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MDMA
Excitotoxicity
Gaba
Glutamate