The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Behavioural Brain Research May 1, 2017 Akihiro Mouri, Yukihiro Noda, Minae Niwa et al.
3,4-Methylenedioxymethamphetamine (MDMA) is known to induce dependence and psychosis in humans. Brain-derived neurotrophic factor (BDNF) is involved in the synaptic plasticity and neurotrophy in midbrain dopaminergic neurons. This study aimed to investigate the role of BDNF in MDMA-induced dependence and psychosis. A single dose of MDMA (10mg/kg) induced BDNF mRNA expression in the prefrontal...
DOI: 10.1016/j.bbr.2017.04.052 (opens in new tab)
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Serotonin
Animals
Mice, inbred c57bl
Mice, knockout
+16