R Feio-Azevedo

Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity.

Archives of Toxicology July 2018 R Feio-Azevedo, V M Costa, D J Barbosa et al.

3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a widespread drug of abuse with known neurotoxic properties. The present study aimed to evaluate the differential toxic effects of MDMA in adolescent and aged Wistar rats, using doses pharmacologically comparable to humans. Adolescent (post-natal day 40) (3 × 5 mg/kg, 2 h apart) and aged (mean 20 months old) (2 × 5 mg/kg, 2 h apart) rats...