Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain
Translational Psychiatry July 16, 2018 Kai‐Chun Yang, Akihiro Takano, Christer Halldin et al. 17 citations
Abstract The serotonin (5-HT) system plays an important role in the pathophysiology and treatment of several major psychiatric disorders. Currently, no suitable positron emission tomography (PET) imaging paradigm is available to assess 5-HT release in the living human brain. [11C]AZ10419369 binds to 5-HT1Breceptors and is one of the most 5-HT-sensitive radioligands available. This study applied...