Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization.
European Journal of Pharmacology November 15, 2017 Alba Iglesias, Marta Cimadevila, Rocío Ailim de La Fuente et al.
The serotonin 2A (5-HT2A) receptor is a G-protein coupled receptor (GPCR) with a conserved disulfide bridge formed by Cys148 (transmembrane helix 3, TM3) and Cys227 (extracellular loop 2, ECL-2). We hypothesized that disulfide bridges may determine serotonin 5-HT2A receptor functions such as receptor activation, functional selectivity and ligand recognition. We used the reducing agent...
DOI: 10.1016/j.ejphar.2017.09.011 (opens in new tab)
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Clozapine pubchem cid
Dl-1,4-dithiothreitol pubchem cid
Disulfide bridges
Phospholipase a2
+4