Relating Observed Psychoactive Effects to the Plasma Concentrations of Delta-9-Tetrahydrocannabinol and Its Active Metabolite: An Effect-Compartment Modeling Approach.
Journal of Pharmaceutical Sciences February 2018 Rakesh Awasthi, Guohua An, Maureen D Donovan et al.
The medical use of marijuana is increasing, yet little is known about the exposure-response relationship for its psychoactive effects. It is well known that the plasma concentrations of the principal psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), do not directly correlate to the observed psychoactive effects. The purpose of this research was to use an effect-compartment...
DOI: 10.1016/j.xphs.2017.09.009 (opens in new tab)
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Clinical pharmacokinetics
Metabolism
Metabolite kinetics
Pharmacokinetic/pharmacodynamic models
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