Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
Neurotoxicology January 2016 I-Hsun Li, Kuo-Hsing Ma, Tzu-Jen Kao et al.
It has been suggested that autophagy plays pathogenetic roles in cerebral ischemia, brain trauma, and neurodegenerative disorders. 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is an illicit drug that causes long-term serotonergic neurotoxicity in the brain. Apoptosis and necrosis have been implicated in MDMA-induced neurotoxicity, but the role of autophagy in MDMA-elicited serotonergic...
DOI: 10.1016/j.neuro.2015.11.009 (opens in new tab)
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MDMA
3-methyladenine
Autophagy
Lc3b
+2