Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice.
Molecular Neurobiology November 2017 The-Vinh Tran, Eun-Joo Shin, Ji Hoon Jeong et al.
Escalating evidence suggests that the impairment of glutathione (GSH)-dependent systems is one of the etiologic factors of schizophrenia. GSH is an important substrate of glutathione peroxidase (GPx). Among GPx isozymes, selenium-dependent GPx (GPx-1) is recognized as a major type, and therefore, this study investigates the role of the GPx-1 gene in abnormal behaviors induced by repeated...
DOI: 10.1007/s12035-016-0239-y (opens in new tab)
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Clozapine
Nrf2 transcription factor
Phencyclidine
Prefrontal cortex
+1