Akiko Inomata

2 papers in the library · publishing 2016-2018

Papers

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Preventive effects of fructose and N-acetyl-L-cysteine against cytotoxicity induced by the psychoactive compounds N-methyl-5-(2-aminopropyl)benzofuran and 3,4-methylenedioxy-N-methamphetamine in isolated rat hepatocytes.

Journal of Applied Toxicology February 2018 Yoshio Nakagawa, Toshinari Suzuki, Akiko Inomata

Psychoactive compounds, N-methyl-5-(2-aminopropyl)benzofuran (5-MAPB) and 3,4-methylenedioxy-N-methamphetamine (MDMA), are known to be hepatotoxic in humans and/or experimental animals. As previous studies suggested that these compounds elicited cytotoxicity via mitochondrial dysfunction and/or oxidative stress in rat hepatocytes, the protective effects of fructose and N-acetyl-l-cysteine (NAC)...

DOI: 10.1002/jat.3523 Full text MDMA 5-mapb N-acetyl-l-cysteine Cytotoxicity +5

Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum.

The Journal of Toxicological Sciences 2016 Tatsu Fuwa, Jin Suzuki, Toyohito Tanaka et al.

We examined the effects of three benzofurans [1-(Benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB), 1-(Benzofuran-2-yl)-N-methylpropan-2-amine (2-MAPB), and 1-(Benzofuran-5-yl)-N-ethylpropan-2-amine (5-EAPB)] on the extracellular monoamine level in mouse corpus striatum by the microdialysis method and compared them with the effects of psychoactive 3,4-Methylenedioxymethamphetamine (MDMA). The...

DOI: 10.2131/jts.41.329 Full text