Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.
The International Journal of Neuropsychopharmacology November 2016 Philip Lr Gaskin, Maria Toledo-Rodriguez, Stephen Ph Alexander et al.
Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning social isolation of rats produces a behavioral syndrome with translational relevance to several core symptoms of schizophrenia. This study uses DNA microarray to...
DOI: 10.1093/ijnp/pyw062 (opens in new tab)
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Glutamate
Isolation rearing
Lamotrigine
Microarray
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