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Mengchen Pu

1 paper in the library · publishing 2016

Papers

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Crystal Structure of the Human Cannabinoid Receptor CB1.

Cell October 20, 2016 Tian Hua, Kiran Vemuri, Mengchen Pu et al.

Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational use. CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. Here, we present the 2.8 Å...

DOI: 10.1016/j.cell.2016.10.004 Full text THC Marijuana Am6538 G protein-coupled receptor +5