The effects of ecstasy (MDMA) on brain serotonin transporters are dependent on age-of-first exposure in recreational users and animals.
PLoS One 2012 Anne Klomp, Bjørnar den Hollander, Kora de Bruin et al.
Little is known on the effects of ecstasy (MDMA, a potent 5-HT-releaser and neurotoxin) exposure on brain development in teenagers. The objective of this study was to investigate whether in humans, like previous observations made in animals, the effects of MDMA on the 5-HT system are dependent on age-of-first exposure. 5-HT transporter (SERT) densities in the frontal cortex and midbrain were...