NeuropsychopharmacologyMay 9, 2026Ana Maria Raymundi, Nathalie Carla Cardoso, Gabriel Costa Lourenço et al.
In PTSD, microglia are more engaged in fear-related circuits, where they participate in fear memory processing responses. The reconsolidation-impairing effect of Δ⁹-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis, is typically linked to cannabinoid type-1 receptor (CB1) signaling. THC also engages peroxisome proliferator-activated receptor gamma (PPARγ), and both...