Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie June 1, 2024 Xue Wu, Gehua Wen, Lei Yan et al. 11 citations
Ketamine, as a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, was originally used in general anesthesia. Epidemiological data show that ketamine has become one of the most commonly abused drugs in China. Ketamine administration might cause cognitive impairment; however, its molecular mechanism remains unclear. The glymphatic system is a lymphoid system that plays a key...