Environmental enrichment enhances the antidepressant effect of ketamine and ameliorates spatial memory deficits in adult rats.
Pharmacology, biochemistry, and behavior July 1, 2024 Deren Aykan, Mert Genc, Gunes Unal 8 citations
Ketamine is a rapid-acting antidepressant associated with various cognitive side effects. To mitigate these side effects while enhancing efficacy, it can be co-administered with other antidepressants. In our study, we adopted a similar strategy by combining ketamine with environmental enrichment, a potent sensory-motor paradigm, in adult male Wistar rats. We divided the animals into four groups...