Dimensional effect profiles in treatment-resistant depression: A naturalistic, prospective head-to-head comparison of arTMS, esketamine nasal spray, and oral brexpiprazole.
Journal of Affective Disorders July 28, 2026 Giacomo d'Andrea, Clara Cavallotto, Ottavia Susini et al.
Treatment-resistant depression (TRD) is a heterogeneous condition in which symptoms such as anhedonia, rumination, and anxiety contribute to persistent disability. Esketamine nasal spray (ESK-NS), accelerated repetitive transcranial magnetic stimulation (arTMS), and adjunctive brexpiprazole represent novel therapeutic options with distinct mechanisms, though their domain-specific effects in...
DOI: 10.1016/j.jad.2026.122333 (opens in new tab)
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Accelerated rtms artms
Brexpiprazole augmentation
Treatment-resistant depression trd