Sex-related differences in intravenous ketamine effects on dissociative stereotypy and antinociception in male and female rats.
Pharmacology, Biochemistry, and Behavior September 22, 2020 Kennett D. Radford, Rina Y. Berman, Michael Zhang et al.
Ketamine, a multimodal dissociative anesthetic drug, is widely used to treat various conditions including acute pain and treatment-resistant depression. We previously reported that subanesthetic doses of intravenous (i.v.) ketamine produced transient dissociative stereotypy and antinociception in male rats. However, sex-related differences in the effects of i.v. ketamine on these measures are...