Shivani Sachdev

Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists.

Pharmacology Research & Perspectives April 2020 Shivani Sachdev, Samuel D Banister, Marina Santiago et al.

Synthetic cannabinoid receptor agonists (SCRAs) are new psychoactive substances associated with acute intoxication and even death. However, the molecular mechanisms through which SCRAs may exert their toxic effects remain unclear-including the potential differential activation of G protein subtypes by cannabinoid receptor type 1 (CB1), a major target of SCRA. We measured CB1-mediated activation...